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Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli.

Titel	Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli.
Publication Type	Journal Article
Year of Publication	2001
Authors	Rubin CT, Sommerfeldt DW, Judex S, Qin Y-X
Journal	Drug discovery today
Volume	6
Issue	16
Pagination	848-858
Date Published	2001 Aug 15
ISSN	1878-5832
Schlüsselwörter	BMS, Osteoporose, Physiologie
Abstract	The identification of anabolic agents for the treatment of metabolic bone disease is a highly prized, and elusive, goal. In searching for the osteogenic (bone-producing) constituents within mechanical stimuli, it was determined that high frequency (10-100 Hz) and low magnitude (<10 microstrain) stimuli were capable of augmenting bone mass and morphology, thereby benefiting both bone quantity and quality. Using animal models, it is shown that these mechanical signals can double bone-formation rates, inhibit disuse osteoporosis and increase the strength of trabecular bone by 25%. Considering that the magnitude of these mechanical signals are several orders of magnitude below those which cause damage to the bone tissue, it is proposed that this modality could be useful in the treatment of metabolic bone diseases.
URL	https://www.researchgate.net/profile/Clinton_Rubin/publication/11848554_Inhibition_of_osteopenia_by_low_magnitude_high-frequency_mechanical_stimuli._Drug_Discov_Today_6848-858/links/0912f50b3bdf988a24000000.pdf
Alternate Journal	Drug Discov. Today