Akademie fuer zellbiologische Regulationsmedizin e.V.

High-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle.

TitelHigh-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle.
Publication TypeJournal Article
Year of Publication2005
AuthorsMurfee WL, Hammett LA, Evans C, Xie L, Squire M, Rubin C, Judex S, Skalak TC
JournalJournal of applied physiology (Bethesda, Md. : 1985)
Volume98
Issue6
Pagination2376-80
Date Published2005 Jun
ISSN8750-7587
SchlüsselwörterBMS, Physiologie, Training
AbstractExtremely low-magnitude (0.3 g), high-frequency (30-90 Hz), whole body vibrations can stimulate bone formation and are hypothesized to provide a surrogate for the oscillations of muscle during contraction. Little is known, however, about the potential of these mechanical signals to stimulate adaptive responses in other tissues. The objective of this study was to determine whether low-level mechanical signals produce structural adaptations in the vasculature of skeletal muscle. Eight-week-old male BALB/cByJ (BALB) mice were divided into two experimental groups: mice subjected to low-level, whole body vibrations (45 Hz, 0.3 g) superimposed on normal cage activities for 15 min/day (n = 6), and age-matched controls (n = 7). After the 6-wk experimental protocol, sections from end and mid regions of the soleus muscles were stained with lectin from Bandeiraea Simplicifolia, an endothelial cell marker, and smooth muscle (SM) alpha-actin, a perivascular cell marker. Six weeks of this low-level vibration caused a 29% decrease in the number of lectin-positive vessels per muscle fiber in the end region of the soleus muscle, indicating a significant reduction in the number of capillaries per muscle fibers. Similarly, these vibrations caused a 36% reduction in SM alpha-actin-positive vessels per muscle fiber, indicating a reduction in the number of arterioles and venules. The decreases in lectin- and SM alpha-actin-positive vessels per muscle fiber ratios were not significant in the mid muscle sections. These results demonstrate the sensitivity of the vasculature in mouse skeletal muscle to whole body, low-level mechanical signals.
URLhttp://jap.physiology.org/content/98/6/2376.long
DOI10.1152/japplphysiol.01135.2004
Alternate JournalJ. Appl. Physiol.

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